Why does the HTT CAG repeat expand across generations, and why almost always through the father? The case for a repair-driven, not replication-driven, mechanism.
The analogy is tempting — a signature protein anchoring a whole disease family in both cases — but only one side of it is actually a subset relationship.
Parkinson's tracks industrialization too closely to be coincidence. Pesticides, solvents, and air pollution all converge on the same loaded gun: the dopamine neuron.
A Colombian woman carried a mutation that should have caused Alzheimer's in her 40s and a genetic quirk that kept her lucid into her 70s — what her brain reveals about where amyloid stops and neurodegeneration begins.
A survey of amyloid, tau, CSF, PET, and blood-based biomarkers for Alzheimer's — and why they're better at ruling pathology in than at predicting exactly when it will strike.
Apoptosis prunes overproduced neurons in development and quietly disposes of injured ones — but which job did the machinery evolve to do first?
Three very different neurological insults converge on the same excitotoxic pathway to necrotic neuron death, but they don't damage the same parts of the brain.