4°

Fragments

7 entries

I write about neuroscience, philosophy, and occasionally poems of love.

Genetic Anticipation of Huntington's DiseaseWhy does the HTT CAG repeat expand across generations, and why almost always through the father? The case for a repair-driven, not replication-driven, mechanism.No. 07
Parkinson's Disease Is to Lewy Body Disease as Alzheimer's Disease Is to Frontotemporal DementiaThe analogy is tempting — a signature protein anchoring a whole disease family in both cases — but only one side of it is actually a subset relationship.No. 06
Parkinson's and the Chemicals of the WestParkinson's tracks industrialization too closely to be coincidence. Pesticides, solvents, and air pollution all converge on the same loaded gun: the dopamine neuron.No. 05
The Curious Case of ARPdVA Colombian woman carried a mutation that should have caused Alzheimer's in her 40s and a genetic quirk that kept her lucid into her 70s — what her brain reveals about where amyloid stops and neurodegeneration begins.No. 04
Biomarkers of Alzheimer's DiseaseA survey of amyloid, tau, CSF, PET, and blood-based biomarkers for Alzheimer's — and why they're better at ruling pathology in than at predicting exactly when it will strike.No. 03
Origins of Apoptosis: Mitigating Injury or Regulating Development?Apoptosis prunes overproduced neurons in development and quietly disposes of injured ones — but which job did the machinery evolve to do first?No. 02
Hypoxia-Ischemia, Seizures, and HypoglycemiaThree very different neurological insults converge on the same excitotoxic pathway to necrotic neuron death, but they don't damage the same parts of the brain.No. 01